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2011-12-22
 
International Institute of Molecular and Cell Biology
is a laureate of Funds for Science 2011 awards in
commercialization of scientific research category for
project: “Tools and methods useful in characterising
the immunotoxic activity of xenobiotic substances”
implemented under the Operational Programme
Innovative Economy, sub-measure 1.3.2 Support
for the protection of industrial property generated
in scientific entities as a result of R&D works.
For more information visit:
http://sciencenetwork.eu/index.php?page=wyniki-konkursu
Funds for Science 2011 brochure.
Grzegorz Chojnowski, Stanisław Dunin-Horkawicz, Katarzyna Kamińska, Irina Tuszyńska, Grzegorz Łach, Tomasz Waleń form Laboratory of Bioinformatics nad Protein Engineering, Małgorzata Figiel and Marcin Jaciuk form Laboratory of Protein Structure, Monika Sokołowska and Marek Wojciechowski form Laboratory of Structural Biology have received funding from Ministry of Science and Higher Education within the Iuvetus Plus Initiative.
Łukasz Świech from Laboratory of Molecular and
Cellular Neurobiology and Jakub Śędziński from
Laboratory of Cell Cortex Mechanics MPG/PAN in
Dresden have received EMBO Long Term Fellowships:
On October 4, 2011, the Polish Prime Minister Donald
Tusk and the Minister of Science and Higher
Education, Prof. Barbara Kudrycka, handed the
nominations for first forty participants of Top 500
Innovators - Science Management Commercialization
Programme. Laureates from IIMCB are Iwona
Cymerman from Laboratory of Molecular and
Cellular Neurobiology, Adam Sobczak former
Post-doc in Laboratory of Neurodegeneration
and Magdalena Powierża from International
Cooperation Unit. For more information please visit:
Dr Elżbieta Purta from Laboratory of Bioinformatics and Protein Engineering and Dr Sokołowska Monika from Laboratory of Structural Biology have received scholarships for outstanding young scientists founded by the Ministry of Science and Higher Education.
Prof. Maciej Żylicz has received title Doctor Honoris Causa of the University of Gdansk for his outstanding contribution to the development of biochemistry and molecular biology, especially for his research on chaperone proteins, also for creating an environment for promoting developement of science in Poland and his contribution to the development of the University of Gdansk.
Dr Marcin Nowotny from Laboratory of Protein Structure is one of the laureates of prestigious ERC grant, he have received founding for his project “Structural studies of Nucleotide Excision Repair complexes”. Interview with Dr Marcin Nowotny was published in Metro:
http://www.emetro.pl/emetro/1,85648,10352311,
Naukowiec_bez_kompleksow.html
Elżbieta Purta from Laboratory of Bioinformatics and Protein Engineering has received Drabikowski Award of the Polish Biochemical Society for the best PhD thesis in 2010. "Identification and characterization of new RNA modifying enzymes". (advisor: Janusz M. Bujnicki)
Laureats of this year’s Jerzy Konorski Award granted annually by Polish Neuroscience Society and Neurobiology Committee PAN for the best research paper in the field of neurobiology are: Marta B. Wiśniewska, Katarzyna Misztal, Wojciech Michowski, Marcin Szczot, Elżbieta Purta, Wiesława Leśniak, Monika E. Klejman, Michal Dąbrowski, Robert K. Filipkowski, Andrzej Nagalski, Jerzy W. Mozrzymas i Jacek Kuźnicki, for their paper: LEF1/ß - Catenin Complex Regulates Transcription of the Cav3.1 Calcium Channel Gene (Cacna1g) in Thalamic Neurons of the Adult Brain, published in Journal of Neuroscience 2010 (30) 14: 4957-4969.
For more please visit:
http://www.ptbun.org.pl/?ma=konor&PHPSESSID=
8edc9d2d84af31a52bf759fb72a849bb
and
http://www.nauka.gov.pl/nauka/sukcesy-uczonych/sukcesy-uczonych/artykul/stare-bialko-w-nowej-odslonie-czy-zblizymy-sie-do-zrozumienia-choroby-afektywnej-dwubiegunowej/
Prof. Maciej Żylicz has been elected a member of the German National Academy of Sciences Leopoldina, and a member of the Senate of the German Max Planck Society, announced FNP.
Founded in 1652, Leopoldina is the oldest scientific society bringing together researchers in the fields of natural sciences and medicine in Germany. In 2008 it was transformed into the German Academy of Sciences. Elected academy members are outstanding scholars from around the world. Currently it has about 1,300 members - 75 percent of them are researchers from Germany, Austria and Switzerland, 25 percent - scientists from 30 other countries. Maciej Żylicz has also been elected a member of the Senate of the Max Planck Society - an independent non-profit institution supporting scientific research in Germany.
Iwona Cymerman form Laboratory of Molecular and Cellular Neurobiology, Adam Sobczak former Post-doc in Laboratory of Neurodegeneration and Magdalena Powierża from International Cooperation Unit were qualified to participate in the first edition of the "Top Innovators - Science, Managment, Comercialization" project.
For more information please visit:
http://www.nauka.gov.pl/ministerstwo/aktualnosci/aktualnosci/
artykul/wyniki-rekrutacji-do-projektu-top-500-innovators/
Ewa Paluch leader of Laboratory of Cell Cortex Machanics MPG / PAN in Dresden is a coauthor of the paper “Polar actomyosin contractility destabilizes the position of the cytokinetic furrow” recently accepted to Nature.
http://www.nature.com/nature/journal/vaop/ncurrent
/full/nature10286.html
Award from Prime Minister for the habilitation thesis to Dr. Jacek Jaworski
http://bip.kprm.gov.pl/g2/2011_07/4881_fileot.pdf
Wojtek Michowski, a former PhD student at the Laboratory of Neurodegeneration, currently a postdoc at the Dana-Farber Cancer Institute in Boston at Dr. Piotr Sicinski's group, is a coauthor on the paper on the role of cyclin D1 in cancerous cells, recently accepted to Nature.
More: http://wiadomosci.onet.pl/nauka/odkrycie-polakow-pomoze-w-walce-z-rakiem,1,4795825,wiadomosc.html
The new Advisory Board for Molecular Genetic Tests and Biobanking was established at the Ministry of Science and Higher Education. The Board is comprised of geneticists, lawyers, representatives of parental support groups, bioeticists, oncologists and laboratory diagnosticians. Prof. Michał Witt was elected a Chairman of the Board.
More: http://www.nauka.gov.pl/ministerstwo/aktualnosci/
aktualnosci/artykul/nowy-zespol-doradczy-ministra/
Annual retreat of IIMCB took place on June 10-11 in Jachranka near Warsaw. The program included the guest speaker lecture delivered by Prof. Urszula Hibner from Institute of Molecular Genetics, Montpellier, CNRS UMR5535 "Epithelial to mesenchymal transition in liver tumorigenesis", and 12 reports of young researchers from the Institute.
The second day of the event was totally devoted to a team building activity.
Starting June 1 the new, rotating deputy director of IIMCB is Jacek Jaworski who will serve on this post till May 31, 2012. Jacek succeeded Janusz Bujnicki.
Nikola Brożko, a graduate student in the Laboratory of Neurodegeneration, was awarded with "Girls of the Future" prize by Ministry of Science and Higher Education and ELLE magazine. More information can be found on the Ministry page: http://www.nauka.gov.pl/ministerstwo/aktualnosci/
aktualnosci/kategoria/1831/artykul/dzis-poznamy-dziewczyny-przyszlosci/
http://forumakademickie.pl/fa/2011/06/poznalismy-dziewczyny-przyszlosci/
On May 14 the latest International Advisory Board meeting took place at IIMCB. The Board evaluated and fully supported for employment extension laboratories of Marcin Nowotny, Marta Miaczynska and Maciej Zylicz. In IAB's opinion all three laboratories performed so far extremely well and their Lab Leaders are widely recognized as top specialist in their fields. Next IAB meeting has been tentatively scheduled for June 1-2, 2012.
On the 26th – 27th of May in Warsaw, "The Relationship of Numerical Simulations and Experimental Methods" workshop will be held.
The aim of this event is presenting and confronting of two points of view, experimental and theoretical, on studies of the same systems, mainly membrane proteins
Registration deadline is on April 20.
For more information and for registration please visit: http://www.chem.uw.edu.pl/simul0511/
Katarzyna Kaminska and dr Grzegorz Chojnowski were awarded with START Fellowship for young scientists by Foundation for Polish Science (FNP).
More information can be found on FNP page: http://www.fnp.org.pl/programy
/aktualne_programy_fnp/stypendia_i_subsydia/
program_start/laureaci_stypendium_start/82_1
The Lancet has published the letter signed by European Commission Science Advisory Group in Health. This letter raises the need for better investment in health research, due to a growing need for high level medical research, which is to be faced by scientists. Members of the European Commission Science Advisory Group in Health, including J. Kuźnicki, have presented recommendations to achieve highest standards in biomedical research. Contents of the letter can be found here…
Prof. Matthias Bochtler, Head of the Laboratory of Structural Biology in IIMCB received grant " Structural biology of methylation and hydroxymethylation" funded by Foundation for Polish Science in the frame of the VI edition of TEAM Programme. The budget of the project is 2 023 940,00 PLN.
There are openings for 3 (paid) MSc students,
2 PhD students and a postdoc this autumn.
Candidates will be selected at a symposium
in July 2011.
Applications in electronic form are invited
until July 1st to mbochtler@iimcb.gov.pl,
citing "FNP Team" in the subject line. List of all laureates can be found on the page of The Foundation for Polish Science: www.fnp.org.pl/programy/aktualne_programy_fnp/
stypendia_i_subsydia/program_team
Prof. Jacek Kuznicki and Dr. hab. Jacek Jaworski received funding from NCBiR (National Centre for Research and Development) for the implementation of 3-year multi-partner ERA NET NEURON/FP7/UE projects.
From February, 1st, Prof. Jacek Kuznicki will lead the Polish group of 5-partner NeuConnect project, titled : ”Novel strategies for the treatment of schizophrenia based on genetic variation of the neural cell adhesion molecule NCAM and enzymes involved in its posttranslational modifications” (240 000 euro) whereas Dr. Jacek Jaworski will be the head of the Polish team within 4-partner AMREPCELL project, titled “Development of new experimental models for mental retardation and autism by iPS technology: generation of human affected and animal model neurons by reprogramming skin fibroblasts and testing gene correction using in vitro and in vivo models.” (350 000 euro)
On the 3 January 2011 Minister Barbara Kudrycka has appointed Prof. Jacek Kuźnicki as a member of the Scientific Policy Committee. Nomination objective was to ensure balanced representation of different scientific fields, different types of research units and areas of socio-economic life.
Main role of the Scientific Policy Committee will be: assisting during elaboration of the documents concerning development of science, science and innovation policy, draft of the state budget and financial plan setting out the founding for science, national and foreign investment priorities, and also giving opinions for drafts of normative acts regarding development of science and innovation, NCN and NCBR activity plans and preparation of substantive evaluation reports from their activities. More information can be found on page:
http://www.nauka.gov.pl/nauka/organy-opiniodawczo-doradcze-ministra/komitet-polityki-naukowej/
On January, 1st, Prof. Janusz Bujnicki has started prestigious ERC grant “Breaking the code of RNA sequence-structure-function relationships: New strategies and tools for modelling and engineering of RNA and RNA-protein complexes”. The 5-year award amounts at 1 500 000 euro.
Katarzyna H. Kamińska and Elżbieta Purta from Laboratory of Bioinformatisc and Protein Engineering have received founding from MNiSW Initiative “Iuventus Plus”.
Jan Kosinski's PhD thesis (advisor: Janusz Bujnicki) obtained the Prime Minister Award and the award of the Polish Bioinformatics Society. Dr. Kosinski is currently a postdoc in Anna Tramontano's laboratory in Rome, supported by EMBO Long Term Fellowship.
Monika Sokołowska form Laboratory od Structural Biology obtained the Prime Minister Award for her PhD thesis: “Structural and biochemical studies of restriction endonucleases BcnI and Hpy99I"c (advisor: Matthias Bochtler).
IIMCB is pleased to inform that it is forming a Technology Transfer Office within the BioCentrum Consortium. More…
On October 23, 2010 in the Maria Grzegorzewska Academy of Special Education in Warsaw a workshop on management of research and higher education was held, organized by Polityka Alumni Association. Prof. Jacek Kuznicki presented a talk: State funds and world-level science - a case of the International Institute of Molecular and Cell Biology.
On 11th October 2010 the Nalecz Institute of Biocybernetics and Biomedical Engineering of the Polish Academy of Sciences hosted the inauguration of the 2010/2011 academic year of the PhD Studies programme. During the event Jan Kosiński, Monika Sokołowska and Roman Szczepanowski from the IIMCB received diplomas and special statuettes for the best doctoral theses of 2009/2010. Diplomas were also awarded to the recipients of scholarships in a project implemented under the Human Capital Operational Programme 2007-2013, promoting entrepreneurship among scientists in the med tech bio sector. Inauguration lectures were delivered by: Prof. Frauke Melchior form the University of Heidelberg, whose speech explained “How SUMO wrestles proteins?”, and Dr. Piotr Borowicz from the Institute of Biotechnology and Antibiotics, who gave a speech about “The commercialization of biosynthetic drugs: Polish recombinant insulin”. For more information visit the BioCentrum Ochota website: http://www.biocentrumochota.gov.pl/
The POMOST Program, is a grant which enables the best researchers who are raising young children to return to advanced research work and to enable pregnant women to conduct research projects financed from external sources, the winner of this years edition is Dr. Magdalena Banach-Orłowska, who received financing in amount of 420 000 PLN.
List of all laureates can be found on the page of The Foundation for Polish Science:
http://www.fnp.org.pl/
Article about POMOST laureats can be found on page:
http://www.rp.pl/artykul/542626.html
IIMCB in collaboration with other BioCentrum Ochota institutes has established a Technology Transfer Unit - Bio-Technology Innovations Platform. The first initiative of the newly founded unit is a stipend programme for PhD students carrying out applied research projects. More information can be found here: www.biotech-ip.pl
September 6th -9th, 2010
More information: www.ecs2010.eu
Katarzyna Kaminska, Elzbieta Purta, Monika Sokolowska and Ewelina Szymanska were awarded with START Fellowship for young scientists by Foundation for Polish Science (FNP)
The Neurofederation selected Dr. Jacek Jaworski's Neuron 2009 Jan 15 paper to feature as Highlight of the Year on the FENS website, as representative of Dutch Neuroscience.
"Going Back to a Changing Poland" (Science Careers, March19, 2010) Agnieszka Chacińska's (Head of the Laboratory of Mitochondrial Biogenesis in IIMCB) profile has been presented in Science.
Institute of Biochemistry and Biophysics and International Institute of Molecular and Cell Biology received a grant "PhD Programme in Molecular Biology: Studies of nucleic acids and proteins - from basic to applied research" funded by the Foundation for Polish Science in the frame of the III edition of the MPD Programme.
Together with other research institutes, IIMCB implements a Project "Centre of Pre-clinical Research and Technology" (CePT), supported by Structural Funds, Operational Programme Innovative Economy (OP IE), Priority 2 R&D Infrastructure, Measure 2.2 Support for development of research infrastructure of scientific entities. The aim of the project is to create the biggest biomedical research centre in Poland within the Ochota Campus. Ten research institutes engaged in CePT will carry out basic and pre-clinical research in fields such as structural and functional analysis of proteins, physicochemistry, nanotechnology of biomaterials, molecular biotechnology, pathophysiology and physiology, oncology, genomics, neurobiology and neurological diseases. IIMCB will create the Centre of Analysis and Function of Protein Structure. The project is coordinated by Medical University of Warsaw. More information about CePT at http://cept.wum.edu.pl/
IIMCB has been awarded funding from the Polish-Norwegian Research Fund for the project “Screening for novel functions of endocytic and autophagic proteins in the regulation of gene expression, cell growth and carcinogenesis”. The project will be carried out by two groups at IIMCB: Laboratory of Cell Biology and Department of Molecular Biology, in collaboration with Prof. Anne Simonsen at Institute of Basic Medical Sciences, University of Oslo. The amount of the grant is 672 572 EUR over a period of 2 years. Coordinator of Polish side: Iwona Pilecka
Matthias Bochtler, Head of the Laboratory of Structural Biology MPG/PAN received a Professorial title from the President of Poland
Poland Regional Report (Nature, 3 December 2009 issue) describes IIMCB as a precursor of modernization of Polish science - see section "INSTITUTIONALIZING INNOVATION", page3.
Agnieszka Chacińska, Head of the Laboratory of the Mitochondrial Biogenesis in IIMCB received grant "Biogenesis and turnover of mitochondrial intermembrane space proteins" funded by Foundation for Polish Science in the frame of the II edition of WELCOME Programme.
She is one of two recipients of this award. The recruitment of the new members of the group will start soon.
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The International Institute of Molecular and Cell Biology in Warsaw (IIMCB) is one of the most modern country´s research institutes in its field. The IIMCB´s research topics cover the wide area of cancer biology, molecular immunology, neurobiology, protein structural biology, bioinformatics/computer modelling, etc. The International Advisory Board, the rules of recruitment of all faculty members through international competition and lack of tenure employment make it unique among Polish research institutions.
Bledowski P, Mossakowska M, Chudek J, Grodzicki T, Milewicz A, Szybalska A, Wieczorowska-Tobis K, Wiecek A, Bartoszek A, Dabrowski A, Zdrojewski T. Medical, psychological and socioeconomic aspects of aging in Poland Assumptions and objectives of the PolSenior project. Exp Gerontol 2011 Dec;46(12):1003-9
Kraszewska MD, Dawidowska M, Szczepanski T,Witt M. T-cell acute lymphoblastic leukaemia: recent molecular biology findings. Br J Haematol; published online: 7 DEC 2011 | DOI: 10.1111/j.1365-2141.2011.08957.x
Czerwoniec A, Bujnicki JM. Identification and modeling of a phosphatase-like domain in a tRNA 2′-O-ribosyl phosphate transferase Rit1p. Cell Cycle 2011 Oct 15;10(20):3566-70
Rother M, Rother K, Puton T, Bujnicki JM. RNA tertiary structure prediction with ModeRNA.
Brief Bioinform. 2011 Nov;12(6):601-13.
Tuszynska I, Bujnicki JM. DARS-RNP and QUASI-RNP: New statistical potentials for protein-RNA docking. BMC Bioinformatics 2011 Aug 18;12(1):348
Bateman A, Agrawal S, Birney E, Bruford EA, Bujnicki JM, Cochrane G, Cole JR, Dinger ME, Enright AJ, Gardner PP, Gautheret D, Griffiths-Jones S, Harrow J, Herrero J, Holmes IH, Huang HD, Kelly KA, Kersey P, Kozomara A, Lowe TM, Marz M, Moxon S, Pruitt KD, Samuelsson T, Stadler PF, Vilella AJ, Vogel JH, Williams KP, Wright MW, Zwieb C. RNAcentral: a vision for an international database of RNA sequences. RNA 2011 Nov;17(11):1941-6.
Liu J, Ganapathy K, Wywial E, Bujnicki JM, Nwogwugwu CA, Nes WD. Effect of substrate features and mutagenesis of active site tyrosine residues on the reaction course catalyzed by Trypanosoma brucei sterol C24-methyltransferase. Biochem J 2011 Nov 1;439(3):413-22
Rother M, Milanowska K, Puton T, Jeleniewicz J, Rother K, Bujnicki JM. ModeRNA server: an online tool for modeling RNA 3D structures. Bioinformatics 2011 Sep 1;27(17):2441-2.
Milanowska K, Rother K, Bujnicki JM. Databases and bioinformatics tools for the study of DNA repair. Mol Biol Int. 2011;2011:475718
Rother K, Potrzebowski W, Puton T, Rother M, Wywial E, Bujnicki JM. A toolbox for developing bioinformatics software. Brief Bioinform 2011 Jul 29. [Epub ahead of print] doi:10.1093/bib/bbr035
Sikorski K, Czerwoniec A, Bujnicki JM, Wesoly J, Bluyssen HA. STAT1 as a novel therapeutical target in pro-atherogenic signal integration of IFNγ, TLR4 and IL-6 in vascular disease. Cytokine Growth Factor Rev. 2011 Aug;22(4):211-9.
Spears JL, Rubio MA, Gaston KW, Wywial E, Strikoudis A, Bujnicki JM, Papavasiliou FN, Alfonzo JD. A single zinc ion is sufficient for an active Trypanosoma brucei tRNA editing deaminase. J Biol Chem 2011 Jun 10;286(23):20366-74.
Mebrhatu M, Wywial E, Ghosh A, Michiels C, Lindner A, Taddei F, Bujnicki JM, van Melderen L, Aertsen A. Evidence for an evolutionary antagonism between Mrr and Type III modification systems. Nucleic Acid Res 2011 Aug 1;39(14):5991-6001
Steinbeck JA, Henke N, Opatz J, Gruszczynska-Biegala J, Schneider L, Theiss S, Hamacher N, Steinfarz B, Golz S, Brüstle O, Kuznicki J, Methner A. Store-operated calcium entry modulates neuronal network activity in a model of chronic epilepsy. Exp Neurol. 2011 Dec;232(2):185-94.
Hokkanen S, Feldmann HM, Ding H, Jung CK, Bojarski L, Renner-Müller I, Schüller U,
Kretzschmar H, Wolf E, Herms J. Lack of Pur-alpha alters postnatal brain development and causes megalencephaly. Hum Mol Genet. 2011 Nov 16. [Epub ahead of print]
Schulz C, Lytovchenko O, Melin J, Chacinska A, Guiard B, Neumann P, Ficner R, Jahn O, Schmidt B, Rehling P. Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex. J Cell Biol. 2011 Nov 14;195(4):643-56
von der Malsburg K, Müller JM, Bohnert M, Oeljeklaus S, Kwiatkowska P, Becker T, Loniewska-Lwowska A, Wiese S, Rao S, Milenkovic D, Hutu DP, Zerbes RM, Schulze-Specking A, Meyer HE, Martinou JC, Rospert S, Rehling P, Meisinger C, Veenhuis M, Warscheid B, van der Klei IJ, Pfanner N*, Chacinska A*, van der Laan M. Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Developmental Cell (2011), doi:10.1016/j.devcel.2011.08.026
*Corresponding authors
Becker T, Wenz LS, Krüger V, Lehmann W, Müller JM, Goroncy L, Zufall N, Lithgow T, Guiard B, Chacinska A, Wagner R, Meisinger C, Pfanner N. The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J Cell Biol. 2011 Aug 8;194(3):387-95.
Kraszewska MD, Dawidowska M, Larmonie NS, Kosmalska M, Sędek L, Szczepaniak M, Grzeszczak W, Langerak AW, Szczepański T, Witt M.
DNA methylation pattern is altered in childhood T-cell acute
lymphoblastic leukemia patients as compared with normal thymic
subsets: insights into CpG island methylator phenotype in T-ALL.
Leukemia. 2011 Aug 12. doi: 10.1038/leu.2011.208.[Epub ahead of print]
Sedzinski J
, Biro M, Oswald A, Tinevez JY, Salbreux G, Paluch E.
Polar actomyosin contractility destabilizes the position of the cytokinetic furrow.
Nature. 2011 Aug 7. doi: 10.1038/nature10286. [Epub ahead of print]
Hupalowska A
, Miaczynska M. The new faces of endocytosis in signaling. Traffic. 2011, Jul 13,doi:10.1111/j.1600-0854.2011.01249.x.
Urbanska A, Sadowski L, Kalaidzidis Y, Miaczynska M. Biochemical Characterization of APPL Endosomes: The Role of Annexin A2 in APPL Membrane Recruitment. Traffic. 2011 Jun 6. doi:10.1111/j.1600-0854.2011.01226.x.
Antonczak AK, Simova Z, Yonemoto IT, Bochtler M, Piasecka A,
Czapinska H, Brancale A, Tippmann EM. Importance of single
molecular determinants in the fidelity of expanded genetic codes.
Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1320-5
Braun S, Humphreys C, Fraser E, Brancale A, Bochtler M, Dale TC.
Amyloid-Associated Nucleic Acid Hybridisation. PLoS One. 2011
6(5):e19125
Audette GF, Lombardo S, Dudzik J, Arruda TM, Kolinski M, Filipek S, Mukerjee S, Kannan AM, Thavasi V, Ramakrishna S, Chin M, Somasundaran P, Viswanathan S, Keles RS, Renugopalakrishnan V.
Protein hot spots at bio-nano interfaces. Materials Today 2011, 14(7-8):360-365 Misztal K, Wisniewska MB, Ambrozkiewicz M, Nagalski A, Kuznicki J.
Wnt-independent constitutive nuclear localization of beta-catenin and
its low degradation rate in thalamic neurons. J. Biol. Chem.
9 July 2011, doi 10.1074/jbc.M111.22966
Clark AG, Paluch E. Mechanics and regulation of cell shape during
the cell cycle. Results Probl Cell Differ. 2011;53:31-73.
Kapitein LC, Yau KW, Gouveia SM, van der Zwan WA, Wulf PS, Keijzer N,
Demmers J, Jaworski J, Akhmanova A, Hoogenraad CC.
NMDA Receptor Activation Suppresses Microtubule Growth and Spine Entry.
J Neurosci. 011 Jun 1;31(22):8194-209
Gruszczynska-Biegala J, Pomorski P, Wisniewska MB, Kuznicki J.
Differential Roles for STIM1 and STIM2 in Store-Operated Calcium
Entry in Rat Neurons. PLoS One 2011 Apr 26;6(4):e19285.
http://www.ncbi.nlm.nih.gov/pubmed/21541286 Sobczak A, Debowska K, Blazejczyk M, Kreutz MR,
Kuznicki J, Wojda U. Calmyrin1 binds to SCG10 protein
(stathmin2) to modulate neurite outgrowth.
Biochimica et Biophysica Acta – Molecular Cell Reserach.
2011 May;1813(5):1025-37 Pilecka I, Sadowski L, Kalaidzidis Y, Miaczynska M. Recruitment of APPL1
to ubiquitin-rich aggresomes in response to proteasomal impairment.
Exp Cell Res. 2011, 317:1093-107 Perycz M, Urbanska A. S, Krawczyk P. S, Parobczak K, Jaworski J. Zipcode Binding Protein 1 Regulates the Development of Dendritic Arbors in Hippocampal Neurons. The Journal of Neuroscience, April 6, 2011; 31(14):5271–5285
Swiech L, Blazejczyk M, Urbanska M, Pietruszka P, Dortland B. R, Malik A. R, Wulf P. S, Hoogenraad C. C, Jaworski J. CLIP-170 and IQGAP1 Cooperatively Regulate Dendrite Morphology, The Journal of Neuroscience, March 23, 2011 • 31(12):4555– 4568 • 4555
Hageman J, van Waarde-Verhagen M, Zylicz A, Walerych D, Kampinga HH. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem J. 2011, 435, 127-142, doi:10.1042/BJ20101247
Jaciuk M, Nowak E, Skowronek K, Tańska A, Nowotny M. Structure of UvrA nucleotide excision repair protein in complex with modified DNA. Nat Struct Mol Biol. 2011 Feb;18(2):191-7. Epub 2011 Jan 16.
Werner M, Purta E, Kaminska KH, Cymerman IA, Campbell DA, Mittra B, Zamudio JR, Sturm NR, Jaworski J, Bujnicki JM, 2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family, Nucleic Acid Res 2011 Feb 9. doi: 10.1093/nar/gkr038
Rother M, Rother K, Puton T, Bujnicki JM, ModeRNA: A tool for comparative modeling of RNA 3D structure, Nucleic Acid Res 2011 Feb 7. [Epub ahead of print]
Rother K, Rother M, Boniecki M, Puton T, Bujnicki JM. RNA and protein 3D structure modeling: similarities and differences. J Mol Model. 2011 Jan 22. [Epub ahead of print]
Azoulay-Alfaguter I, Yaffe Y, Licht-Murava A, Urbanska M, Jaworski J, Pietrokovski S, Hirschberg K, Eldar-Finkelman H. Distinct molecular regulation of GSK-3alpha isozyme controlled by its N-terminal region. Functional role in calcium/calpain signaling. J Biol Chem. 2011 Jan 25. [Epub ahead of print]
Diz-Muñoz A,Krieg M, Bergert M, Ibarlucea-Benitez I, Muller DJ, Paluch E, Heisenberg CP. Control of directed cell migration in vivo by membrane-to-cortex attachment. PLoS Biol. 2010 Nov 30;8(11):e1000544
Bukowy Z, Zietkiewicz E, Witt M. In vitro culturing of ciliary respiratory cells-a model for studies of genetic diseases. J Appl Genet. 2010 Dec 2. [Epub ahead of print]PMID: 21125367
Geremek M,
Bruinenberg M, Zietkiewicz E, Pogorzelski A,Witt M, Wijmenga C. Gene expression studies in cells from primary ciliary dyskinesia patients identify 208 potential ciliary genes. Hum Genet. 2010 Dec 7. [Epub ahead of print]
Zietkiewicz E, Nitka B, Voelkel K, Skrzypczak U, Bukowy Z, Rutkiewicz E, Huminska K, Przystalowska H, Pogorzelski A, Witt M. Population specificity of the DNAI1 gene mutation spectrum in primary ciliary dyskinesia (PCD). Respir Res. 2010 Dec 8;11(1):174. [Epub ahead of print]
Zubrienė A, Gutkowska M, Matulienė J, Chaleckis R, Michailovienė V, Voroncova A, Venclovas C, Zylicz A, Zylicz M, Matulis D. Thermodynamics of radicicol binding to human Hsp90 alpha and beta isoforms. Biophys Chem. 2010 Nov;152(1-3):153-63. Epub 2010 Oct 12.
Figiel M, Chon H, Cerritelli SM, Cybulska M, Crouch RJ, Nowotny M. ,The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutieres syndrome defects. J Biol Chem. 2010 Dec 22. [Epub ahead of print]
Rychlik MP, Chon H, Cerritelli SM, Klimek P, Crouch RJ, Nowotny M. Crystal Structures of RNase H2 in Complex with Nucleic Acid Reveal the Mechanism of RNA-DNA Junction Recognition and Cleavage. Mol Cell. 2010 Nov 24;40(4):658-70.
Bojarski L, Debowska K, Wojda U, In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia. Progress in Neuropsychopharmacology & Biological Psychiatry 34 (2010) 1367–1374
Piano D, El Alaoui S, Korza H J, Filipek R, Sabala I, Haniewicz P, Buechel C, De Sanctis D and Bochtler M, Crystallization of the Photosystem II core complex and its chlorophyll binding subunit CP43 from transplastomic plants of Nicotianatabacum, Photosynthesis Research DOI:10.1007/s11120-010-9597-x
Husain N, Obranić S, Koscinski L, Seetharaman J, Babić F, Bujnicki JM, Maravić-Vlahoviček G, Sivaraman J Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit Nucleic Acids Res 2011 [Epub ahead of print Nov 9 2010] doi:10.1093/nar/gkq1033
Milanowska K, Krwawicz J, Papaj G, Kosinski J, Poleszak K, Lesiak J, Osinska E, Rother K, Bujnicki JM REPAIRtoire – a database of DNA repair pathways Nucleic Acids Res 2011 [Epub ahead of print Nov 4 2010] doi:10.1093/nar/gkq1087
Gajda MJ, Tuszynska I, Kaczor M, Bakulina AY, Bujnicki JM FILTREST3D: discrimination of structural models using restraints from experimental data Bioinformatics 2010 [Epub ahead of print Oct 17 2010] doi:10.1093/bioinformatics/btq582
Abrahams JP, Apweiler R, Balling R, Bertero MG, Bujnicki JM, Chayen NE, Chène P, Corthals GL, Dyląg T, Förster F, Heck AJ, Henderson PJ, Herwig R, Jehenson P, Kokalj SJ, Laue E, Legrain P, Martens L, Migliorini C, Musacchio A, Podobnik M, Schertler GF, Schreiber G, Sixma TK, Smit AB, Stuart D, Svergun D, Taussig MJ "4D Biology for Health and Disease" Workshop Report N Biotechnol 2010 [Epub ahead of print Oct 14 2010]doi:10.1016/j.nbt.2010.10.003
Sokolowska M
, Czapinska H, Bochtler M. Hpy188I-DNA pre- and post-cleavage complexes--snapshots of the GIY-YIG nuclease mediated catalysis. Nucleic Acids Res. 2010 Oct 8. doi: 10.1093/nar/gkq821
Firczuk M, Wojciechowski M, Czapinska H, Bochtler M. DNA intercalation without flipping in the specific ThaI-DNA complex. Nucleic Acids Res. 2010 Sep 21. doi: 10.1093/nar/gkq821
Stefaniuk M, Swiech L, Dzwonek J, Lukasiuk K. Expression of Ttyh1, a member of the Tweety family in neurons in vitro and in vivo and its potential role in brain pathology. J Neurochem. 2010 Sep 27. doi: 10.1111/j.1471-4159.2010.07023.x. [Epub ahead of print]
J. Kieper, C. Lauber, O. Gimadutdinow, A. Urbańska, I.Cymerman, M. Ghosh, B. Szczesny, G. Meiss, Production and characterization of recombinant protein preparations of Endonuclease G-homologs from yeast, C. elegans and humans. Protein Expr Purif. 2010 Sep;73(1):99-106. Epub 2010 Apr 9
Walerych D
, Gutkowska M, Klejman MP, Wawrzynow B, Tracz Z, Wiech M, Zylicz M, Zylicz A. ATP binding to Hsp90 is sufficient for effective chaperoning of p53 protein. J Biol Chem. 2010 Aug 5. [Epub ahead of print]
G. Adler, M. Parczewski, E. Czerska, B. Łoniewska, M. Kaczmarczyk, J. Gumprecht, W. Grzeszczak, A. Szybińska, M. Mossakowska, A. Ciechanowicz; An age-related decrease in factor V Leiden frequency among Polish subjects, J Appl Genet 51(3), 2010, pp. 337–341
Klemba, M. Kowalewska, W. Kukwa, K. Tonska, A. Szybińska, M. Mossakowska, A. Scinska, P. Golik, K. Koper, J. Radziszewski, A. Kukwa, A. M. Czarnecka, E. Bartnik; Mitochondrial genotype in vulvar carcinoma - cuckoo in the nest. Journal of Biomedical Science 2010
Miaczynska M
, Bar-Sagi D. Signaling endosomes: seeing is believing. Curr Opin Cell Biol. 2010, 22, 535-540
Kosinski J
, Hinrichsen I, Bujnicki JM, Friedhoff P, Plotz G. Identification of Lynch syndrome mutations in the MLH1-PMS2 interface that disturb dimerization and mismatch repair. Hum Mutat. 2010 Aug;31(8):975-82
Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L. New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA. Nucleic Acids Res. 2010 Jun 4. doi:10.1093/nar/gkq451
Uberti D, Cenini G, Bonini SA, Barcikowska M, Styczynska M, Szybinska A, Memo M. Increased CD44 Gene Expression in Lymphocytes Derived from Alzheimer Disease Patients. Neurodegenerative Dis 2010;7:143–147
Kolinski M
, Filipek S. Study of a structurally similar kappa opioid receptor agonist and antagonist pair by molecular dynamics simulations. J Mol Model. 2010 Oct;16(10):1567-76
Michowski W,
Ferretti R, Wisniewska MB, Ambrozkiewicz M, Beresewicz M, Fusella F, Skibinska-Kijek A, Zablocka B, Brancaccio M, Tarone G, Kuznicki J. Morgana/CHP-1 is a novel chaperone able to protect cells from stress. BBA - Mol Cell Res, 2010 Sep;1803(9):1043-1049
Bialopiotrowicz E
, Kuzniewska B, Kachamakova-Trojanowska N, Barcikowska M, Kuznicki J, Wojda U. Cell cycle regulation distinguishes lymphocytes from sporadic and familial AD patients. Neurobiology of Aging 2010 Jun 10. [Epub ahead of print]
Chojnowski G, Bochtler M. DIBER: protein, DNA or both? Acta Crystallogr D Biol Crystallogr. 2010 Jun;66(Pt 6):643-53
Sobhanifar S, Schneider B, Löhr F, Gottstein D, Ikeya T, Mlynarczyk K, Pulawski W, Ghoshdastider U, Kolinski M, Filipek S, Güntert P, Bernhard F, Dötsch V. Structural investigation of the C-terminal catalytic fragment of presenilin 1. Proc. Natl. Acad. Sci. USA, May 25, 2010, 107(21): 9644–9649
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Piechota M, Korostynski M, Solecki W, Gieryk A, Slezak M, Bilecki W, Ziolkowska B, Kostrzewa E, Cymerman I, Swiech L, Jaworski J, Przewlocki R. The dissection of transcriptional modules regulated by various drugs of abuse in the mouse striatum. Genome Biology 2010, 11:R48doi:10.1186/gb-2010-11-5-r48
Polosak J, Roszkowska-Gancarz M, Kurylowicz A, Owczarz M, Dobosz P, Mossakowska M, Szybinska A, Puzianowska-Kuznicka M. Decreased expression and the Lys751Gln polymorphism of the XPD gene are associated with extreme longevity. Biogerontology 2010 Jun;11(3):287-97
Wisniewska M, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W, Klejman M, Dąbrowski M, Filipkowski R, Nagalski A, Mozrzymas J, Kuznicki J. LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain. J Neurosci 2010 Apr 7; 30(14):4957-4969
Kirkegaard T, Roth AG, Petersen NH, Mahalka AK, Olsen OD, Moilanen I, Zylicz A, Knudsen J, Sandhoff K, Arenz C, Kinnunen PK, Nylandsted J, Jäättelä M. Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 2010 Jan 28;463(7280):549-53
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Spooren A, Rondou P, Debowska K, Lintermans B, Vermeulen L, Samyn B, Skieterska K, Debyser G, Devreese B, Vanhoenacker P, Wojda U, Haegeman G, Van Craenenbroeck K. Resistance of the dopamine D4 receptor to agonist-induced internalization and degradation. Cell Signal 2009 Apr;22(4):600-9
Khan F, Furuta Y, Kawai M, Kaminska KH, Ishikawa K, Bujnicki JM, Kobayashi I. A putative mobile genetic element carrying a novel type IIF restriction-modification system (PluTI). Nucleic Acids Res 2010 May;38(9):3019-30
Zhou X, Chua TK, Tkaczuk KL, Bujnicki JM, Sivaraman J. The crystal structure of Escherichia coli spermidine synthase SpeE reveals a unique substrate-binding pocket. J Struct Biol 2010 Mar;169(3):277-85
Pukancsik M, Bekesi A, Klement Eva, Hunyadi-Gulyas E, Medzihradszky K, Kosinski J, Bujnicki JM, Alfonso C, Rivas G, Vertessy B. Physiological truncation and domain organization of a novel uracil-DNA degrading factor. FEBS J 2010 Mar;277(5):1245-59
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, Purta E, Hansen LH, Bujnicki JM, Vester B, Long KS. Insights into the structure, function, and evolution of the Radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. Nucleic Acids Res 2010 Mar;38(5):1652-63
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Gentsch M, Kaczmarczyk A, van Leeuwen K, de Boer M, Kaus-Drobek M, Dagher MC, Kaiser P, Arkwright PD, Gahr M, Rösen-Wolff A, Bochtler M, Secord E, Britto-Williams P, Saifi GM, Maddalena A, Dbaibo G, Bustamante J, Casanova JL, Roos D, Roesler J. Alu-repeat-induced deletions within the NCF2 gene causing p67-phox deficient chronic granulomatous disease (CGD), Hum Mutat, 2010 Feb;31(2):151-8
Chojnowski G, Breer K, Narczyk M, Wielgus-Kutrowska B, Czapinska H, Hashimoto M, Hikishima S, Yokomatsu T, Bochtler M, Girstun A, Staron K, Bzowska A. 1.45 Å resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state, Biochem Biophys Res Commun 2010, 391, 703-8
BOOKS
"Becoming Transnational Professional"
Izabela Wagner
Izabela Wagner “Becoming Transnational Professional” is a book about how the persons involved in the study are members of the international community of scholars, like a local, educated mainly in one researcher's educational system is born international specialist.
Some research was done in our Institute.
More:
http://scholar.com.pl/sklep.php?md=products&id_c=1&id_p=2081&
"Hematologia molekularna - patogeneza, patomechanizmy
i metody badawcze"
Editors: Michał Witt, Tomasz Szczepański, Małgorzata Dawidowska
Ośrodek Wydanictw Naukowych
This is a new book edited at IIMCB by Michal Witt, being the first Polish language monography devoted to molecular aspects of hematooncological diseases and modern treatment and diagnostic procedures. A separate section deals with application of molecular biology methods for diagnosis of hematological disorders.
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